Accommodation is available at the below venues:

The Blackwell Inn hotel, on The Ohio State Campus. Please call +1 614-247-4000 and quote PGRN2024 to benefit from the group discount

Hyatt House: 633 W 5^th Avenue, 2.1 miles to the Blackwell, 1.2 miles to Pomerene Hall

Aloft: 1295 Olentangy River Road, 2 miles to the Blackwell, 1.5 miles to Pomerene Hall

Springhill Suites: 1421 Olentangy River Road, 1.9 miles to the Blackwell, 1.3 miles to Pomerene Hall

Scientific Meeting 2024 Program at a Glance

Monday September 23^rd – Pomerene Hall Ideation Zone, Room 320, 1760 Neil Avenue

All of Us Research Workshop (registration required)

1:00 - 3:15P All of Us Workshop Part 1- Advancing PGx Research using AllofUS

3:15 - 3:30P BREAK

3:30 - 5:30P All of Us Workshop Part 2 - Using AllofUs Researcher Workbench

3:30 - 5:30P PGRN Implementation Working Group In-Person Meeting (registration not required)

6:00 - 7:30P PGRN Social Event   - Come catch up with old and new colleagues at The Bottleshop, 237 King Avenue. Walking distance from Pomerene Hall.

Tuesday September, 24^th – Blackwell Conference Center, 2110 Tuttle Park Place

8:30A - 9:30A  Keynote 1 - Genomics-based diagnosis in the practice of pediatric medicine: A platform for precision medicine and discovery- Elaine Mardis, Nationwide Children's Hospital

9:30A - 9:45A BREAK

9:45A - 11:15A - Demonstrating Clinical Utility of PGx Testing: Study Designs and Evidence Generation

11:15A - 12:30P - Perspectives on Evidence Thresholds in PGx (Panel)

Hamilton Hall, Ohio State University Medical Center, 1645 Neil Ave, Columbus, Ohio 43210

The workshop will immediately follow the Pharmacogenomics Global Research Network meeting scheduled for September 23-25 at Ohio State University.

All roundtable and platform sessions will include onsite and virtual (Zoom) presentations and discussions

Workshop registration is free of charge to all participants. Refreshments and meals are provided at no cost to the speakers and to a limited number of onsite participants. Anyone interested in presenting or attending (either onsite or virtually) should send their contact information to David W. Hein at david.hein@louisville.edu as soon as possible since the number of additional onsite attendees for whom meals will be provided at no cost may be limited.

Special thanks to the Society of Toxicology for funding, the University of Louisville for logistic support and to Ohio State University for logistic support and hosting the workshop.

Organizing Committee

• David W. Hein, University of Louisville, Louisville, Kentucky USA
• Sotiria Boukouvala, Democritus University of Thrace, Alexandroupolis, Greece
• Giannoulis Fakis, Democritus University of Thrace, Alexandroupolis, Greece

The workshop will immediately follow the Pharmacogenomics Global Research Network meeting scheduled for September 23-25 at Ohio State University..

September 25

Zoom information:

Join Zoom Meeting

https://osu.zoom.us/j/95514640276?pwd=10CiXWSi1XaaWjlfn5edS2TXbMo2RI.1

Meeting ID: 955 1464 0276

Password: 438711

One tap mobile

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Registration and refreshments (2:30-3:00 pm)

Welcome by David W. Hein, Conference Chair and Institutional Officials; Introduction of Organizing Committee Members; funding acknowledgements; schedule updates

Conference Roundtable (3:00-5:00 pm)

NAT nomenclature committee and PharmVar expert panel updates on NAT2 allele nomenclature

o   Sotiria Boukouvala and Georgia Papanikolaou, Democritus University of Thrace, Alexandroupolis, Greece

CPIC update on NAT2 allele function
o   David W. Hein, University of Louisville School of Medicine, Louisville, Kentucky USA

The use of language related to human diversity in pharmacogenetics: The case of NAT2

o   Kyle B. Brothers, University of Louisville School of Medicine, Louisville, Kentucky USA

Platform Session I:  Diversity in NAT2 and other pharmacogenes (5:00-6:00 pm)

Evolution of human diversity in NAT2 and other pharmacogenes
o   Estella S. Poloni, University of Geneva, Genève, Switzerland

Phenotypic Distribution of Acetylation and Hydroxylation Profiles Based on NAT2, CYP2E1, CYP3A4, and CYP3A5 Genes Across Brazil: Implications for Adverse Drug Reactions in Leprosy
o   Adalberto R. Santos, Oswaldo Cruz Institute, Rio de Janeiro, Brazil (via Zoom)

Conference Dinner (7 – 10 pm; restaurant and location to be announced)

September 26

Join Zoom Meeting

https://osu.zoom.us/j/96235493030?pwd=QlNGw60Hatpsmjg6h1SsFqPgXqNZpb.1

Meeting ID: 962 3549 3030

Password: 270444

One tap mobile

+16468769923,,96235493030#,,,,0#,,270444# US (New York)

+16513728299,,96235493030#,,,,0#,,270444# US (Minnesota)

Breakfast (8:00- 8:30 am)

Platform Session II:  NATs in chronic diseases (8:30 to 10:30 am)

The polymorphic enzymes NAT2, GSTM1, and GSTT1 and urinary bladder cancer risk after the structural change in the local chemical industry
o   Klaus Golka, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), Dortmund, Germany (via Zoom)

The role of arylamine N-acetyltransferases in chronic degenerative diseases: exploring their possible function in the immune system

o   Diana Portales-Perez, Autonomous University of San Luis Potosí, Mexico

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders

Kyung U. Hong, Western New England University, Springfield, Massachusetts, USA

Differential expression of NAT1 in hormone receptor positive vs. negative female breast cancer
o   Giannoulis Fakis, Democritus University of Thrace, Alexandroupolis, Greece

Refreshment Break (10:30 am to 11:00 am)

Platform Session III: NAT2 allele definition and function (11:00 am to 12:30 pm

Single nucleotide and copy number variation at the NAT2 locus, assessed according to PharmVar criteria and nomenclature
o   Georgia Papanikolaou, Democritus University of Thrace, Alexandroupolis, Greece

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes 
o   Mariam R. Habil, University of Louisville, Louisville, Kentucky, USA

The effect of the rs1799931 c.857G>A (p.Gly286Glu) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure
o   David W. Hein, University of Louisville, Louisville, Kentucky USA 

Conference lunch and roundtable discussion of NAT2 allele function (12:30 – 1:30 pm)

Platform Session IV: NATs and mitochondrial function (1:30 – 2:30 pm)

The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction
o   Rodney F. Minchin, University of Queensland, Brisbane, Australia (via Zoom)

Stable isotope tracing reveals an altered fate of glucose in N-acetyltransferase 1 knockout breast cancer cells
o    James TF Wise, Louisiana State University, Baton Rouge, Louisiana, USA

Platform Session V: NAT functions in xenobiotic metabolism and beyond (2:30-5:30 pm)

N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substance
o   Raul Salazar-Gonzalez, Discovery Life Sciences,  Malden, Massachusetts, USA
   Bacterial NATs in xenobiotic metabolism
o   Maria-Giusy Papavergi, Democritus University of Thrace, Alexandroupolis, Greece (currently at Harvard Medical School, Cambridge, Massachusetts, USA)

Bacterial NATs in secondary metabolism
o   Dionysios Patriarcheas, Democritus University of Thrace, Alexandroupolis, Greece (currently at University of West Virginia, Morgantown West Virginia, USA

Assaying NATs of human and other primates
o   Ioanna Stavrakaki, Democritus University of Thrace, Alexandroupolis, Greece (currently at University of Crete, Heraklion, Greece; via Zoom)

NATs in plant-pathogenic fungi
o   Anthony E. Glenn, US Department of Agriculture, Agricultural Research Service, Athens, Georgia, USA (via Zoom)

Unraveling the evolutionary origins of microbial NATs: from transglutaminases to acetyltransferases, and from xenobiotic biotransformation to the biosynthesis of secondary metabolites

o   Sotiria Boukouvala, Democritus University of Thrace, Alexandroupolis, Greece

A summary of antibody reagents  against NATs - all available to a good home!
o   Edith Sim, University of Oxford, Oxford, UK (via Zoom)

Refreshment Break

Platform Session VI: UDP- UDP-glucuronosyltransferases (5:30 – 6:30 pm)

Drug-drug interactions between cannabinoids and UGT-mediated metabolism of opioids and benzodiazepines
o   Philip Lazarus, State University of New York at Buffalo, Buffalo, New York, USA

Role of N-glycosylation in the activity, function, and cellular localization of human uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6)
o   Yuejian Liu, University of British Columbia, Vancouver, British Columbia, Canada (via Zoom) 

Comprehensive characterization of rat and mouse UDP-glucuronosyltransferases

o   Yuji Ishii, Kyushu University, Fukuoka, Japan (via Zoom)

Conference Dinner (7 – 10 pm; restaurant and location to be announced)

As part of the PGRN 2024 Scientific Meeting, we are also pleased to invite you to take part in the AllofUs Workshop on September 23rd. Please note that this will require a separate ticket from your Scientific Meeting registration. Please find details below:

Workshop Part 1- Advancing PGx Research using AllofUS

Learn about the AllofUs research program, program updates, data availability, with specific use examples

•  Intro/Welcome (5 min)

•  AoUProgram Overview  (recruitment, goals, demographics)

•  Types of data and accessing it (workbench basics, types data, and resources)

•  Accessing, strengths and weaknesses of AoU

•  Lightning talks 

Workshop Part 2 - Using AllofUs Researcher Workbench

• Workbench in depth

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