Research in Progress - Laura Ramsey, PhD

Early Career Presentation:
 'Identification of efficacious treatment for glioblastoma (GBM) by applying computational drug sensitivity imputation to novel GBM avatars."
Danielle Maeser, PhD Student
University of Minnesota

Research in Progress:
"Pharmacogenetics of Antidepressants in Pediatric Patients with Anxiety and Depression"
Dr. Ramsey will present on the retrospective studies of pediatric patients with pharmacogenetic test results that were treated with antidepressants. Her lab found that pharmacogenetic phenotypes were associated with response, tolerability, and length of hospitalization in children with anxiety and/or depression treated with escitalopram, sertraline, and fluoxetine. They also performed pharmacokinetic modeling of escitalopram and sertraline based on CYP2C19 phenotypes to predict doses that would provide equivalent exposure across CYP2C19 phenotypes.

Laura Ramsey, PhD
Co-Director of the Genetic Pharmacology Service
Cincinnati Children’s Hospital Medical Center