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PHONT Profile

PGRN Ontology Network Resource


Principal Investigator

Christopher G. Chute, M.D., Dr.Ph.

Host Institution

Mayo Clinic, Rochester, MN

PGRN 2010 Retreat Poster

PHONT Poster


 PHONT Publications
TOP Publications PHONT Publications

Abstract (Updated April 2014)

The PGRN Ontology Network Resource (PHONT) aims to develop a framework for representing pharmacogenomic data in comparable and consistent forms, facilitate interoperability, and information liquidity. To accomplish this aim, we are pursuing projects within three related themes.

1. Providing standardized phenotype definitions. Standardized phenotypes, such as treatment response and clinical outcomes, are essential for uniformly identifying patient cohorts. PHONT is working with national initiatives to develop methods and tooling for creating and using standardized phenotype definitions across multiple EMR systems.

2. Providing standardized data element definitions and pharmacogenomically relevant value sets. Collecting research and clinical data in study-neutral formats enables secondary use of the data. Using data elements from PGRN studies, PHONT is developing tooling to facilitate their representation using standardized clinical element models.

3. Providing standardized representations of pharmacogenomic guidelines. Computable representations of pharmacogenomic guidelines will encourage consistent implementation among institutions and help to minimize maintenance of clinical decision support rules. To facilitate this, PHONT is developing structured and coded representations of the published CPIC guidelines.

Team Members

Christopher G. Chute, M.D., Dr.PH.
Principal Investigator;Professor of Biomedical Informatics
Phone: (507) 284-5506
Jyotishman Pathak, Ph.D.
Co-Investigator; Assistant Professor of Biomedical Informatics
Phone: (507) 538-8384
Robert R. Freimuth, Ph.D.
Co-Investigator; Assistant Professor of Biomedical Informatics
Phone: (507) 284-0753
Qian Zhu, Ph.D.
Research Associate, Biomedical Informatics
Phone: (507) 538-0187